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发育及DNA损伤反应调节基因1的研究进展 被引量：1

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摘要 发育及DNA损伤反应调节基因1(regulated in development and DNA damage responses 1,REDD1)又称为RTP801,是一个新近发现的低氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)靶基因,在细胞和整体动物缺氧缺血模型中其表达显著升高,随着研究的深入,发现其对多种细胞刺激均能产生应激反应,在细胞凋亡过程中发挥着重要的调节作用;RTP801受到多种细胞信号通路的调控,研究其功能和作用机制可为临床缺血性疾病和肿瘤的防治等提供新的思路。
作者 吴小梅 杜方 朱俐
机构地区 南通大学航海医学研究所
出处 《生理科学进展》 CAS CSCD 北大核心 2007年第3期273-276,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(30570675) 江苏省高校自然科学研究基金(04KJB310113) 南通市社会发展科技计划(S5041)资助课题
关键词 发育及DNA损伤反应调节基因1 低氧诱导因子-1 细胞凋亡
分类号 Q343.12 [生物学—遗传学]
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参考文献10

  • 1Goda N,Dozier SJ,Johnson RS.HIF-1 in cell cycle regulation,apoptosis,and tumor progression.Antioxid Redox Signal,2003,5:467～473.
  • 2Shoshani T,Faerman A,Mett I,et al.Identification of a novel hypoxia-inducible factor 1-responsive gene,RTP801,involved in apoptosis.Mol Cell Biol,2002,22:2283～2293.
  • 3Schwarzer R,Tondera D,Arnold W,et al.REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.Oncogene,2005,24:1138～1149.
  • 4Wang Z,Malone MH,Thomenius MJ,et al.Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals.J Biol Chem,2003,278:27053～27058.
  • 5Lin L,Stringfield TM,Shi X,et al.Arsenite induces a cell stress-response gene,RTP801,through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein.Biochem J,2005,392(Pt 1):93～102.
  • 6Ellisen LW,Ramsayer KD,Johannessen CM,et al.REDD1,a developmentally regulated transcriptional target of p63 and p53,links p63 to regulation of reactive oxygen species.Mol Cell,2002,10:995～1005.
  • 7Brugarolas J,Lei K,Hurley RL,et al.Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.Genes Dev,2004,18:2893～2904.
  • 8Wang H,Kubica N,Ellisen LW,et al.Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.J Biol Chem,2006,281:39128～39134.
  • 9Malagelada C,Ryu EJ,Biswas SC,et al.RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.J Neurosci,2006,26:9996～10005.
  • 10Brafman A,Mett I,Shafir M,et al.Inhibition of oxygen-induced retinopathy in RTP801-deficient mice.Invest Ophthalmol Vis Sci,2004,45:3796～3805.

同被引文献15

  • 1Schneider A, Younis RH, Gutkind JS. Hypoxia-induced energy stress inhibits the roTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma [ J ]. Neoplasia 2008, 10( 1 1 ) : 1295-1302.
  • 2Wang Z, Malone MH, Thomenius M J, et al. Dexametha-sone-induced gene 2 (dig2) is a novel p ro2survival stress gene induced rap idly by diverse apop totic signals [ J ]. J Biol Chem, 2003,278 (29) :27053-27058.
  • 3Lin L, Stringfield TM, Shi X, et al. Arsenite induces a cell stress- response gene, RTP801, through reactive oxygen species and tran- scrip t-ion factors Elk-1 and GCAAT/ enhancer-binding protein [J]. Biochem J, 2005, 392 (Pt 1) : 93-102.
  • 4Semenza GL. Involvement of hypoxia-inducible factor 1 in human cancer [J]. Intern Med, 2002, 41 (2):79-83.
  • 5Choi KS, Bae MK, Jeong JW, et al. Hypoxia-induced angiogenesis during carcinogenesis [J]. J Biochem Mol Biol, 2003,36( 1 ) :120- 127.
  • 6Huang LE, Burm HF. Hypoxia-inducible factor and its biomedical relevance [J]. J Biol Chem, 2003, 278(22) :19575-19578.
  • 7Coda N, Dozier S J, Johnson RS. HIF-1 in cell cycle regulation, ap- optosis, and tumor progression [ J]. Antioxid Redox Sigual, 2003,5 (4) :467-473.
  • 8Shoshani T, Faerman A, Mett I, et al. Identification of a novel hy- poxia-inducible factor 1-responsive gene, RTPS01, involved in ap- optosis [ J]. Mol Cell Biol, 2002,22(7) :2283-2293.
  • 9Schwarzer R, Tondera D, Arnold W, et al. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinoshol 3-kinase [J]. Oncogene, 2005,24(7) :1138-1149.
  • 10Lee M J, Kim JY, Suk K, et al. Identification of the hypoxi, a-inducible factor 1 alpha responsive HGTD-P gene as a mediator in the mi- tochondrial apoptotic pathway [ J ]. Mol Cell Biol, 2004,24 ( 9 ) : 3918-3927.

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生理科学进展
2007年 第3期

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