小鼠自然衰老模型的血脂水平及抗氧化能力的评价

The Level of Plasma Lipoprotein and Antioxidative Activity in Aged Mice Model

目的:对小鼠自然衰老模型进行血脂及抗氧化方面的评价。方法:取15月龄和25日龄健康昆明种小鼠,分为青年组和老年组,测定其血脂中的血浆总胆固醇(TC)、血浆甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),抗氧化方面的超氧化物歧化酶(SOD)的活性,血清丙二醛(MDA)的含量和单胺氧化酶(MAO)的活性,并进行比较。结果:小鼠自然衰老模型的血脂中,TC及LDL-C升高,SOD的活性降低(P<0.05),MDA的含量显著升高(P<0.01),MAO的活性升高(P<0.05)。结论:自然衰老后,血脂明显增高,抗氧化的能力降低。

Objective： To assess the level of plasma lipoprotein and the antioxidative activity in aged mice model. Methods： 15 month-old and 25 day-old of Kunming species mice were divided into the young and the aged mice group. The level of plasma lipoprotein , including TC, TG, HDL-C and LDL-C, and plasma SOD activity , MDA level, MAO activity were studied. Result： In normal aged mice model, the levels of TC and LDL-C of the lipoprotein in plasma were increased , and the activity of SOD was decreased significantly （P〈0. 05）, and the level of MDA in plasma and activity of MAO were increased obviously （P〈0. 01, P〈0.05）. Conclusion： The level of plasma lipoprotein and MDA increase and the activity of SOD decreases, and MAO increases significantly in aged mice model.