摘要
目的:研究姜黄素对人低分化鼻咽癌细胞系亚克隆株CNE-2Z-H5生长、增殖的作用。方法:应用姜黄素体外干预培养人低分化鼻咽癌细胞系亚克隆株CNE-2Z-H5,以绘制生长曲线、MTT及平板克隆形成实验观察姜黄素对CNE-2Z-H5细胞生长、增殖的作用。结果:细胞生长曲线、MTT及平板克隆形成实验均表明姜黄素对CNE-2Z-H5细胞生长、增殖具有抑制作用,并呈剂量效应关系。同时,超过一定浓度的姜黄素对CNE-2Z-H5细胞还具有细胞毒作用,可以体外杀伤CNE-2Z-H5细胞。结论:姜黄素可以有效抑制CNE-2Z-H5细胞的生长和增殖,具有明显的量效关系,可能对鼻咽癌的治疗具有一定价值。
Objective.To investigate the effects of curcumin on growth and proliferation in CNE-2Z-H5 cells. Methods： Cells growth curves, MTT assay and plate colony formation rate were used to identify the effects of curcumin on growth and proliferation of CNE-2Z-H5 ceils. Results： The growth and proliferation of CNE-2Z-H5 ceils were inhibited significantly by curcumin compared with the control group, which was in dose dependent manner. At the same time when the dose of curcumin was higher, curcumin also could kill CNE-2Z-H5 cells obviously in vitro. Conclusion：The curcumin can inhibit the growth and proliferation of CNE-2Z-H5 ceils effectively. It has applicable value in therapy of NPC.
出处
《医学理论与实践》
2007年第7期747-749,共3页
The Journal of Medical Theory and Practice
关键词
姜黄素
鼻咽肿瘤
增殖
肿瘤治疗
Curcumin, Nasopharyngeal neoplasms, Proliferation, Tumor therapy
