藤黄科植物Garcinia maingayii的化学成分(英文)

Chemical Constituents of Garcinia maingayii

目的:研究藤黄科植物Garcinia maingayii的化学成分。方法:采用柱层析方法分离和纯化化合物,根据各种波谱和X-衍射分析鉴定化合物结构。结果:从该植物的茎皮中分离并鉴定出5种化合物:isoxanthochymol(1) ,camboginol(2)5 ,7 ,2′,5′-tetrahydroxy flavan-3-ol(3),stigmasterol (4)和griffipavixanthone (5) ,其中1和2为polyisoprenyl benzophenones类化合物,5为bixanthone类化合物。结论:以上5种化合物都是首次从该植物中分得,其中化合物1、2和5对小鼠P388白血病细胞有细胞毒活性,其IC50分别为1.47 ,4.90和0.42μg·mL-1。

AIM： To study the bioactive chemical constituents of Garcinia maingayii Hook. METHODS： Repeated column chromatography was used for separation of compounds and spectroscopic techniques and X-ray analysis were used for structure determination. RESULTS： Five known compounds, isoxanthochymol （1）, camboginol （2）5, 7, 2＇, 5＇-tetrahydroxy flavan-3-ol （3）, stigmasterol （4） and griffipavixanthone （5） were obtained from hexane and acetone extracts of stem barks of the plant. Compounds 1, 2 and 5 showed high potential in vitro cytotoxicity against in P388 murine leukemia cells with IC50 1.47, 4.90 and 0.42μg·mL^-1, respectively. CONCLUSION： Compounds 1-5 were first reported from this plant.