区域定位药控载体魔芋微球的合成制备研究

The Synthesis of the KMB-Drug Delivery Carrier of Area Location

采用纯化魔芋葡甘聚糖复配黄原胶,在水溶液中物理共混合成了粘度和韧性均较佳的凝胶块,进一步用干法和湿法分别制备了魔芋微球,运用激光粒度分布仪分析了不同分散剂下的魔芋微球粒径,最后以魔芋微球作为药物释放的载体,初步探讨了体温下肠液和胃液中药物尼莫地平(NMP)的释放特性.实验结果显示:干法制备的魔芋微球在二甲亚砜中团聚现象较少,平均粒径为6.08μm;在液体石蜡中,湿法制备了粒径小且均匀的魔芋微球,粒径为2.98μm;释药实验中,药物缓释效果明显,释放时间超过24 h以上.魔芋微球的研究为制备药物通用区域定位缓控释载体提供了新的可借鉴思路.

The purified konjac glucomannan（KGM） was blended with Xanthan gum in aqueous solution to prepared gel, which was valued by its viscosity and tenacity. The konjac micro-balls（KMBs） were prepared in drying and wetting method respectively. The average diameter of the KMBs, which were dispersed in different dispersants, was analyzed with laser particle size analyzer. To a carrier of drug deliver, the delivery characteristics of the NMP, which embedded in KMB, was discussed. The results show that KMB was well dispersed in DMSO, and its average diameter was 6.08μm; In paraffin, KMB was homogeneous dispersed with smaller diameter（2.23μm）. In the behavior of drug delivery, the characteristics of drug sustained-release were obvious, and the delivery time was more than 24h. The research of KMB offers a new way in preparing the common drug delivery carrier of area location.