美托洛尔治疗老年慢性心力衰竭临床研究

Therapeutic effects of metoprolol on chronic heart failure

目的探讨美托洛尔治疗老年慢性心力衰竭的疗效和安全性。方法76例老年慢性心力衰竭患者随机分为治疗组37例和对照组39例。对照组采用心力衰竭的常规治疗方案,治疗组在心力衰竭常规治疗方案基础上加用美托洛尔,治疗1年。结果治疗组心功能改善、左室舒张末径减小,左室射血分数明显增加,与对照组比较差异有统计学意义(P<0.05)。结论美托洛尔治疗老年慢性心力衰竭安全有效。

Objective To investigate the efficacy and safety of metoprolol in patients with chronic heart failure（CHF）. Methods 76 patients with CHF were randomly divided into metoprolol group （n= 37）and control group （n= 39）, standard therapeutic scheme is used in control group, standard therapeutic scheme ± metoprolol was used in metoprolol group. The treatment courses were 1 year in both groups. Results Left ventricular end-diastolic diameter（LVEDD）reduced and left ventricular ejection fraction（LVEF）increased in metoprolol group with significant difference comparing with control group （P〈0.05）. The adverse reaction of metoprolol were mostly dizziness, asthenia, bradycardia and hypotension,no damage of liver and or kidney function or changes of hemogram, blood-lipid, electrolyte and blood sugar were found. Conclusions Metoprolol is effective and safe in treatment of CHF.