基因治疗病毒载体的研究进展

Study Advancement of Viral Vector for Gene Therapy

基因转移载体是基因治疗的重要组成部分,包括病毒载体和非病毒载体。目前应用的病毒载体主要有逆转录病毒载体、腺病毒载体、腺病毒相关病毒、慢病毒载体、单纯疱疹病毒载体等。不同的病毒载体各有利弊。随着对病毒载体的不断改造完善,提高其基因转移效率和安全性,病毒载体将在基因治疗中继续发挥重要作用。

Gene transfer vector is the important ingredient in gene therapy, which includes virus vector and nan-vires vector. At present, the mainly applied virus vectors are retroviral vector, adenovirus vector adenovirus-associated virus slow virus vector, herpes simplex virus vector and so on. Different viruses have their own advantages and disadvantages. With the increasing reform and consummation of virus vector, it can play its important role continuously in gene therapy by promoting its efficacy and safty in gene transfer.