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细胞因子信号转导抑制因子SOCS基因甲基化与肿瘤 被引量：1

Methylation of Suppressor of cytokine Signal Transduction Gene(SOCS)and Tumor
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摘要 细胞因子信号转导抑制因子(SOCS)基因的异常甲基化与多种人类肿瘤的发生、发展有明显的相关性。SOCS基因的甲基化沉默导致JAK/STAT途径的结构激活,从而造成了致癌基因和增殖相关基因的激活并最终导致了肿瘤的形成。 The abnormal methylation of Suppressor of cytokine Signal Transduction Gene （SOCS） has obvious relationship with the oecurance and development of tumor. The raethylation-mediated silencing of SOCS gene results in constitutive activation of the JAK/STAT pathway. The activation of the pathway thus may cause an activation of oncogenes or growth-associated genes and eventually leads to oncogenesis.
作者 姜雨刚 何松美 谢毅 林木生
机构地区 广东医学院肝胆外科研究所
出处 《医学综述》 2007年第7期514-516,共3页 Medical Recapitulate
关键词 SOCS基因 甲基化 肿瘤 Suppressor of cytokine siganaling Methylation Tumout
分类号 R730.231 [医药卫生—肿瘤]
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参考文献20

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同被引文献15

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医学综述
2007年 第7期

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