期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Toll样受体在胎盘中的表达研究 被引量：2

Study of Toll-like Receptor Expression in the Placenta
下载PDF
导出
摘要 Toll样受体（TLRs）是近几年发现的天然免疫受体,它们能特异性地识别病原微生物的结构成分,激活天然免疫。目前已克隆鉴定出13种TLR,其中TLR1-10在胎盘中有表达,表明TLRs在胎盘的先天性免疫过程中可能起重要作用。 Toll-like receptor is the new found natural immune receptor in recent years, which can specificly recognize the structural component of pathogenic microorganism,and activate natural immune. At present, about 13 kinds of TLR receptor have been cloned and identified successfully, among which TLR1-10 have somewhat expression in placenta. These data shaowed that TLR may play an important role in natural immune of placenta .
作者 袁文常 刘建玲 刘慧姝
机构地区 西北大学生命科学学院 广州医学院第三附属医院产科
出处 《医学综述》 2007年第11期801-803,共3页 Medical Recapitulate
基金 国家留学基金资助项目(NO20844001) 教育部留学回国人员科研启动基金项目(教外司留[2005]383号)
关键词 胎盘 TOLL样受体 基因表达 信号传递 Placenta Toll-like receptors Gene expression Signal transmission
分类号 R714.56 [医药卫生—妇产科学]
  • 相关文献

参考文献15

  • 1Medzhitov R,Preston-Hulburt P,Janeway CA Jr.A human homologue of the Drosophila Toll protein signal sactivation of adaptive immunity[J].Nature,1997,388(6640):394-397.
  • 2Martin MU,Wesche H.Summary and comparison of the signaling mechanisms of the Toll/Interleukin-1 receptor family[J].Biochim Biophys Acta,2002,1592(3):265-280.
  • 3Takeda K,Kaisho T,Akira S.Toll-like receptors[J].Annu Rev lmmunol.2003.21:335-376.
  • 4Hemmi H,Takeuchi O,Kawai T,et al.A Toll-like receptor recognizes bacterial DNA[J].Nature,2000,408(6813):740-745.
  • 5Sato S,Sugiyama M,Yamamoto M,et al.Toll/IL-1 receptor domaincontaining adaptor inducing IFN-beta(TRIF)associates with TNF receptor-associated factor 6 and TANK-binding kinase 1.and activates two distinct transcription factors,NF-kappa B and IFN-regulatory factor-3,in the Toll-like receptor signalling[J].Immunol,2003,171,(8):4304-4310.
  • 6Holmlund U,Cebers G,Dahlfors AR,et al.Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta[J].Immunology,2002,107(1):145-151.
  • 7Mitsunari M,Yeshida S,shoji T,et al.Macrophage-activating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E2 via toll-like receptor 2 in human placental trophoblast cells[J].J Repred Immunol,2006.72(1-2):46-59.
  • 8Abrahams VM,Bole-Aldo P,Kim YM,et al.Divergent trophoblast responses to bacterial products mediated by TLRs[J].J Immunol,2004,173(7):4286-4296.
  • 9Beijar EC,Mallard C,Powell TL.Powell.Expression and subcellular localization of TLR-4 in term and first trimester human placenta[J].Placenta,2006,27(2-3):322-326.
  • 10Kim YM,Romero R,Chaiworapongsa T,et al.Tinnakorn Chaiworapongsa.To11-like receptor-2 and-4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis[J].Am J Obstet Gynecol,2004,191(4):1346-1355.

同被引文献22

  • 1王兆莉,郭晓玲.胎膜早破导致母婴感染的相关因素分析[J].中国感染控制杂志,2005,4(1):33-35. 被引量：36
  • 2Newton ER. Chorioamnionitis and intraamniotic infection [J]. Clin Obstet Gynecol, 1993,36(4) : 795-808.
  • 3Kim YM, Romero R, Chaiworapongsa T, et al. Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioam- nionitis[J]. Am J Obstet Gynecol, 2004, 191 (4) : 1346-1355.
  • 4Abrahams VM, Bole-Aldo P, Kim YM, et al. Divergent trophoblast responses to bacterial products mediated by TLRs [J]. J Immunol, 2004,173 ( 7 ) : 4286-4296.
  • 5Bauer EM. High mobility group box 1 contributes to the pathogene- sis of experimental pulmonary hypertension via activation of Toll- like receptor 4 [ J]. Mol Med,2013,8 ( 18 ) : 1509-1518.
  • 6Cunningham FC, Gant NF, Leveno K J, et al. Williams Obstetrics (21st ed) [ M]. New York: McGraw-Hill Com. Inc, 2001 : 569- 570.
  • 7Sersam LW. Inflammatory markers in pre-eclampsia and related conditions[ J]. Int J Gynaeeol Obstet ,2009,105 ( 1 ) :69-70.
  • 8Xie F,Hu Y,Turvey SE,et al. Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia [J]. BJOG,2010,117 ( 1 ) :99-108.
  • 9Murphy SR,LaMarca BB,Cockrell K,et al. Role of endothelin in mediating soluble fms-like tyresine kinase l-induced hypertension in pregnant rats [ J ]. Hypertension,2010,55 (2) :394-398.
  • 10Pineda A, Verdin-Terdn SL, Camacho A, et al. Expression of Toll- like receptor TLR-2, TLR-3, TLR-4 and TLR-9 is increased in placentas from patients with preeclampsia [ J ]. Arch Med Res, 2011,42(5) :382-391.

引证文献2

二级引证文献9

医学综述
2007年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部