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白血病血管形成机制及PTK787的应用前景

A Mechanism of Leukemia Angiopoiesis and Application Prospect of PTK787
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摘要 白血病的发生和发展与肿瘤血管的形成密不可分,近年来,随着对白血病血管形成机制的研究逐步深入,血管内皮生长因子(VEGF)/血管内皮生长因子受体(VEGFR)信号转导途径被证实为血管形成的核心环节,作用于该环节的受体酪氨酸激酶抑制剂PTK787(新药代码)应用于白血病治疗的研究开始受到人们的重视。现就白血病的血管形成机制、VEGF/VEGFR信号转导途径及PTK787在白血病治疗中的应用前景作一综述。 The development and genensis of Leukemia is closely related to tumor angiopoiesis.With the development of furhter study of leukemia angiopoiesis, VEGF/VEGFR signal patlaway has been testified to be the key links in angiopoiesis,of which the receptor protein tyrosine kinase PTK 787 is attracting more attention from people.This article reviews leukemia about its angiopoiesis ,VEGF/VEGFR signal and application prospect of PTK787 in the treatment of leukemia.
作者 田川 陈日玲
机构地区 广东医学院附属医院
出处 《医学综述》 2007年第12期883-885,共3页 Medical Recapitulate
基金 湛江市科学技术局科技投标项目(2K0307)
关键词 白血病 血管形成 受体酪氨酸激酶抑制剂 血管内皮生长因子 PTK787 Leukemia Angiopoiesis Receptor tyrosine kinase inhibitor Vascular endothelial growth factor PTK787
分类号 R733.7 [医药卫生—肿瘤]
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参考文献20

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医学综述
2007年 第12期

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