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Ski/SnoN与转化生长因子β信号通路的研究 被引量：3

Study of Ski/SnoN Protein and TGF-β Signal Pathway
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摘要 Ski/SnoN为一类具有高度同源性的核内癌蛋白,近年研究表明其与肿瘤的发生和发展、胚胎的发育和组织纤维化等密切相关。许多的实验和资料显示在转化生长因子β信号通路中,Ski/SnoN作为辅助调节因子,抑制Smad蛋白介导的转录活性,从而调节基因的表达,以实现多种生物学功能。本文主要就Ski/SnoN的结构、分布、作用机制及其与疾病的关系简要综述。 Ski and SnoN are a kind of intranuclear oncoprotein with high homology. Recent researches showed that Ski and SnoN is closely related to the genesis and development of tumor, growth of embryon, tissue fibrosis and so on. Many experiments and data showed that Ski/SnoN can regulate the gene expression to achieve many biological functions by inhibiting Smad protein -mediated transeriptional activity in TGF-β signal pathway as assisted regulatory factor. This article reviews Ski/SnoN about its structure, distribution, mechanism of action and its relationship with diseases.
作者 张爱青 甘卫华 陈荣华
机构地区 南京医科大学第二附属医院儿科
出处 《医学综述》 2007年第13期972-975,共4页 Medical Recapitulate
关键词 Ski/SnoN 转化生长因子Β 信号转导 Ski/SnoN TGF-β Signal transduction
分类号 R392.1 [医药卫生—免疫学]
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参考文献20

  • 1Reed JA,Bales E,Xu W,et al.Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo:functional implications for transforming growth factor b signaling[J].Cancer Res,2001,61 (22):8074-8078.
  • 2Nakao A,Afrakhte M,Moren A,et al.Indentificafion of Smad 7,a TGF-β-inducible antagonist of TGF-β signalling[J].Nature,1997,389(6651):631-635.
  • 3He J,Tegen SB,Krawitz AR,et al.The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins[J].J Biol Chem,2003,278(33):30540-30547.
  • 4Ueki N,Hayman MJ.Direct interaction of Ski with either Smad 3 or Smad 4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling[J].J Biol Chem,2003,278(35):32489-32492.
  • 5Miznide M,Hara T,Furuya T,et al.Two short segments of Smad 3 are important for specific interaction of Smad 3 with c-Ski and SnoN[J].J Biol Chem,2003,278 (1):531-536.
  • 6Wu JW,Krawitz AR,Chai J,et al.Structural mechanism of Smad 4recognition by the nuclear oncoprotein Ski:insights on Ski-mediated repression of TGF-beta signaling[J].Cell,2002,111 (3):357-367.
  • 7Prunier C,Pessah M,Ferrand N,et al.The oncoprotein Ski acts as an antagonist of transforming gowth factor-beta signaling by suppressing Smad 2 phosphorylation[J].J Biol Chem,2003,278 (28):26249-26257.
  • 8Harada J,Kokura K,Kanei-Ishii C,et al.Requirement of the co-repressor homeodomain-interacting protein kinase 2 for Ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation[J].J Biol Chem,2003,278(40):38998-38005.
  • 9Denissova NG,Liu F.Repression of endogenous Smad 7 by Ski[J].J Biol Chem,2004,279(27):28143-28148.
  • 10Briones-Orta MA,Sosa-Garrocho M,Moreno-Alvarez P,et al.SnoN corepressor binds and represses smad 7 gene promoter[J].Biochen Biophy Res Commun,2006,341(3):889-894.

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医学综述
2007年 第13期

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