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TGF-β/Smad信号通路与慢性移植性肾病的研究进展 被引量：4

TGF-β/Smad Signal Pathway and Chronic Allograft Nephropathy
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摘要 慢性移植性肾病是导致肾移植失败的主要原因,其发病机制目前尚不清楚。TGF-β/Smad信号通路在慢性移植性肾病的形成和发展中发挥了重要作用,而Smad通路仍是目前所公认的介导TGF-β胞内反应的主要通路。本文将Smads在慢性移植性肾病中TGF-β/Smads信号转导通路的作用研究进展予以综述,旨在为开辟防治慢性移植性肾病的新途径提供理论和实验依据。 Chronic allograft nephropathy （CAN） is the main cause resulting in failure of renal transplantation,whose pathogenesis is not clear at present. TGF-βSmad signaling pathway plays an important role in the form and development of CAN, and Smad pathway is the main pathway mediating intracellular reaction of TGF- β. This article reviews the progress in effect of TGF-β/Smad signal pathway in order to provide theory and experiment base for new pathway in the prevention and cure of CAN.
作者 陈细明 廖贤平
机构地区 武警广东总队医院器官移植中心
出处 《医学综述》 2007年第1期46-48,共3页 Medical Recapitulate
关键词 慢性移植性肾病 TGF-Β/SMAD信号通路 SMAD蛋白 Chronic allograft nephropathy TGF-β/Smad signal pathway Smad protein
分类号 R617 [医药卫生—外科学] R692 [医药卫生—泌尿科学]
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参考文献20

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二级参考文献21

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共引文献22

同被引文献37

引证文献4

二级引证文献35

医学综述
2007年 第1期

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