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脂联素及其受体表达的调节因素 被引量：4

Regulating Factors of Adiponectin and its Receptors Expression
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摘要 脂联素作为肥胖患者中第一个下调的脂肪细胞因子,是所有脂肪细胞因子中惟一的负性调节激素,具有降糖、增加胰岛素敏感性、抗炎和抗动脉粥样硬化等作用,脂联素的这些效应必须通过脂联素受体AdipoRl和AdipoR2的介导来完成。对脂联素及其受体调节因素的进一步研究可为其相关疾病的防治提供一条新的思路。 Adiponectin,the first down regulating fat cell cytokine,is the only down-regulation hormone in all fat cell cytokines,which has anti-diabetic,insulin-sensitizing,anti-inflammatory and anti-atherogenic effects,these effects must be mediated by its receptors including AdipoRl and AdipoR2.Further researching of adiponectin and its receptors may offer a new alternative of related diseases in their prevention and cure.
作者 陈明 李兴
机构地区 山西医科大学第二医院内分泌科
出处 《医学综述》 2007年第8期575-577,共3页 Medical Recapitulate
关键词 糖尿病 脂联素 脂联素受体 Diabetic Adiponectin Adiponection receptors
分类号 R977.1 [医药卫生—药品]
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参考文献18

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同被引文献58

  • 1李江华,肖全红,汤长发.脂肪细胞因子的负反馈作用与肥胖和2型糖尿病的形成(英文)[J].中国临床康复,2006,10(40):172-175. 被引量：2
  • 2谢群芳,王叶舟,戴文森.血清胱抑素C清除值估测肾小球滤过率的临床评价[J].中国误诊学杂志,2007,7(9):1969-1970. 被引量：56
  • 3魏文青.脂联素的研究现状与展望[J].标记免疫分析与临床,2007,14(2):122-125. 被引量：24
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  • 5Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome, J Clin Invest, 2006, 116 (7): 1784-1792.
  • 6Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors, Endocr Rev, 2005, 26(3): 439-451.
  • 7Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome, Nature, 2006, 444(7121): 881-887.
  • 8Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects, Nature, 2003, 423(6941): 762-769.
  • 9Gable DR, Hurel S J, Humphries SE. Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease, Atherosclerosis, 2006,188(2): 231-244.
  • 10Yamauchi T, Nio Y, Maki T, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions, Nat Med, 2007, 13(3): 332-339.

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医学综述
2007年 第8期

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