膀胱移行细胞癌中树突状细胞的表达及其临床意义

Expression of dendritic cells on bladder transitional cell cacinoma and its dinical significance

目的探讨不同临床病理分级、预后的膀胱移行细胞癌中树突状细胞(DC)的表达及意义。方法对60例膀胱移行细胞癌进行S-100蛋白多克隆抗体免疫组化染色,并用正常膀胱黏膜作为对照,随访3年观察预后。结果不同病理分级、临床分期和预后的膀胱移行细胞癌中,其DC数量相互比较差异均有显著意义(P<0.01),浅表型DC数量高于浸润型,Ⅰ级高于Ⅱ级和Ⅲ级,膀胱癌组高于正常组,复发组低于未复发组。结论DC在机体有肿瘤时作为抗原递呈者出现,其数量随着肿瘤病理分级的增高而降低。DC可以作为膀胱移行细胞癌的肿瘤标志物,成为判断膀胱癌患者预后的指标之一。

Objective To explore the expression of dendritic cells and its clinical significance in patients with different clinical pathological and prognositic of bladder transitional cell carcinoma （BTCC）. Methods The dendritic cells were measured in 60 cases of BTCC by IHC using the polyclonal antibody to S-100 pro- tein, compared with 15 normal bladder tissues. The patients were followed-up 3.years. Results There was significant difference in the amounts of DCs between patients with different pathologic grades, clinical stages of BTCC compared with the normal tissue（P〈0.01 ）. The amounts of DCs in the recurrent tumours were signif- icantly lower than those non-recurrent group. BTCC＇s DCs were higher than that of the normal bladder tissue. Conclusion The amounts of DCs in tumour decreased with the grades rising. The DC may be used as a tumour maker in the BTCC, and it is more valuable for prognosis and recurrence of BTCC.