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Hyper-IL-6的结构与生物学功能研究进展 被引量：1

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作者 郄春花 秦波
机构地区 重庆医科大学病毒性肝炎研究所
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2007年第3期281-283,287,共4页 Chinese Journal of Immunology
基金 重庆市科委基金资助项目(No.2004[54]号)
关键词 生物学功能 结构信息 功能研究进展 可溶性白细胞介素6受体 基因工程技术 FISCHER 细胞因子 SIL-6R
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献22

  • 1Fischer M,Goldschmitt J,Peschel C et al.A bioactive designer cytokine for human hemotopoietic progenitor cell expansion[J].Nature Biotechnol,1997;15:142-145.
  • 2Boulanger M J,Chow D,Brevnova E E et al.Hexameric structure and assembly of the interleukin-6/IL-6α-receptor/gp130 complex[J].Science,2003;300(7):2101-2104.
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  • 5Igaz P,Horvath A,Horvath B et al.Soluble interleukin-6 receptor(sIL-6R) makes IL-6R negative T cell line respond to IL-6;it inhibits TNF production[J].Immunol Letter,2000;71(3):143-148.
  • 6Rakemann T,Niehof M,Kubicka S et al.The designer cytokine hyper-intreleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro[J].J Biol Chem,1999;274(3):1257-1266.
  • 7Peters M,Blinn G,Jostock T et al.Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration[J].Gastroenterol,2000;119(6):1163-1171.
  • 8Zvibel I,Brill S,Kevital R et al.Chimeric molecule IL-6/soluble receptor is a potent mitogen for fetal hepatocytes[J].J Cell Physiol,2004;200(2):245-252.
  • 9Galun E,Zeira E,Pappo O et al.Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury[J].FASEB J,2000;4(13):1979-1987.
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同被引文献16

  • 1Fischer M,Goldschmitt J,Peschel et al.A bioactive designer cytokine for human hematopoietic progenitor cell expansion[J].Nature Biotechnology,1997;15:142-145.
  • 2Drucker C,Gewiese J,Malchow S et al.Impact of interleukin-6 classic-and trans-signaling on liver damage and regeneration[J].J Autoimmun,2010;34(1):29-37.
  • 3Cressman D E,Greenbaum L E,Deangelis R A et al.Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice[J].Science,1996;274:1379-1383.
  • 4Male Peters,Guido Blinn,Fian Solem et al.In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6[J].Immunol,1998;161:3575-3581.
  • 5Yeoh GC,Ernst M,Rose-John S,Akhurst B et al.Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation[J].Hepatoology,2007;45(2):486-494.
  • 6Richards P J,Nowell M A,Horiuchi S et al.Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis[J].Arthritis Rheum,2006;54(5):1662-1672.
  • 7Thampi H B S,Manoj G,Leelamma,S et al.Dietary fiber and lipid peroxidation.Effects of dietary fiber on levels of lipids and lipid peroxides in high fat diet[J].Indian J Experimental Biology,1991;29(6):563-567.
  • 8Venditti P,Di M S.Effect of training on antioxidant capacity,tissue damage,and endurance of adult male rats[J].Inter J Sports Medicine,1997;18(7):497-502.
  • 9Delenda C.Lentiviral vectors:optimization of packaging,transduction and gene expression[J].J Gene Med,2004;6(Supple 1):S125-S138.
  • 10Blomer U,Gruh I,Witschel H et al.Shuttle of lentiviral vectors via transplanted cells in vivo[J].Gene Ther,2005;12(1):67-74.

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中国免疫学杂志
2007年 第3期

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