摘要
采用滴制法制备乌索酸滴丸,以滴丸的圆整度、质量差异及硬度等作为综合评定指标,优选出滴丸的最佳工艺为乌索酸与基质配比为1∶5,滴制温度为90℃,滴距为10 cm,冷凝剂的温度为15℃.同时采用RP-HPLC法测定滴丸中乌索酸含量为(5±6.1%)mg,乌索酸滴丸的体外溶出度75 min内比片剂提高232.8%,比乌索酸胶囊提高12.5%.
Ursolic acid dropping pills were prepared by dropping method, Optimum prescription and dropping conditions were that the ratio of Ursolic acid to PEG was 1 ： 5, the temperature of dropping was 90 ℃, the temperature of coolant liquid was 15 ℃ and the dropping distance was 10 cm by using spherical degree, disintegrability time and hardness as comprehensive evaluation indicator. The content of ursolic acid in dropping pills was （5 ± 6.1% ） nag by using RP-HPLC method. The dissolution rate of ursolic acid dropping pills in vitro was increased by 232.8% and 12.5% than that of its tablet and capsule within 75 min, respectively.
出处
《江西师范大学学报（自然科学版）》
CAS
北大核心
2007年第3期259-261,共3页
Journal of Jiangxi Normal University(Natural Science Edition)
基金
国家"863"计算重点资助项目(2002AA2Z3217)
关键词
乌索酸滴丸
制备工艺
滴制法
溶出度
高效液相色谱
ursolic acid dropping pills
preparation technology
dropping method
dissolution rate
HPLC
