Ⅱ型糖尿病合并神经病变的多因素分析

Multi-factor analysis of type Ⅱ diabetes mellitus with neuropathy

目的了解Ⅱ型糖尿病合并神经病变的患病率,并进一步分析影响糖尿病神经病变相关的危险因素。方法收集在本院住院治疗的150例Ⅱ型糖尿病患者及60例正常体检者的病史和临床生化资料,Ⅱ型糖尿病患者根据有无合并神经病变分成两组。比较各组间的临床资料,使用单因素及多因素相关分析方法,分析Ⅱ型糖尿病合并神经病变相关的危险因素。结果Ⅱ型糖尿病神经病变患病率46.7%。糖尿病神经病变组和糖尿病无神经病变组比较,SBP、糖尿病病史、吸烟史、FPG、HbA1c与空腹C肽在两组之间有明显差别,具有统计学意义(P<0.05)。且SBP、糖尿病病史、吸烟史、FPG,PBG,和HbA1c为Ⅱ型糖尿病患者合并神经病变的独立因素。结论神经病变在Ⅱ型糖尿病人群中有较高的患病率,其发病与众多的因素有关。

Objective To investigate the incidence of diabetic neuropathy in population of type Ⅱ diabetes mellitus and its risk factors. Methods 150 patients with type Ⅱ diabetes mellitus and 60 normal people were collected. Diabetes mellitus patients were divided into two groups： type Ⅱ diabetes mellitus group and type Ⅱ diabetes mellitus with neuropathy. The main associated factors were collected and analyzed by one-way ANOVA and logistic regression. Results The morbidity of neuropathy in diabetes mellitus was 46.7%. Compared with the group of type Ⅱ diabetes mellitus without neuropathy, the levels of SBP, diabetic history, smoking, FPG, HbAlc and C-Peptide in type Ⅱ diabetes mellitus with neuropatby showed an obviously statistical difference （P 〈 0.05） , and the higher SBP, FPG, PBG, HbAlc and longer duration of diabetes, history of smoking were found to be correlated with type Ⅱ diabetic with neuropathy, respectively. Conclusions The prevalance rate of neuropathy in diabetes mellitus is high, and it is affected by many factors.