生物反馈结合舍曲林治疗焦虑症的对照研究

A control study of biofeedback plus sertraline in the treatment of anxiety disorder

目的探讨生物反馈结合舍曲林治疗焦虑症的疗效。方法将焦虑症患者按随机分组法分为反馈治疗结合舍曲林组(反馈组45例)和舍曲林药物治疗组(对照组44例),观察6周,分别于治疗前及治疗后第2、6周采用汉密顿焦虑量表(HAMA)评定两组临床疗效。结果反馈组治疗后2,6周末HAMA评分均较治疗前显著下降(P<0.05或P<0.01),而对照组治疗6周末差异有显著性(P<0.01);治疗6周末两组间评分及临床疗效差异无显著性(P>0.05);反馈组用药剂量低于对照组(P<0.05)。结论两组方法治疗焦虑症均有显著疗效,生物反馈结合舍曲林治疗的效果优于单纯舍曲林治疗,且可明显缩短疗程,减少医疗开支。

Objective To explore the clinical effect of biofeedback plus sertraline in the treatment of anxiety disorder. Methods The patients for anxiety disorder were assigned randomly to biofeedback plus sertraline treatment group （biofeedback group, n = 45） and sertraline treatment group （control group, n =44）. Effects were evaluated with Hamilton Anxiety Scale （HAMA） before and after 2, 6- week treatment respectively, Results There were significant differences in the HAMA scores of biofeedback group after 2, 6-week treatment （P 〈 0.05 or P 〈 0.01 ）, and there were significant differences of control group after 6-week treatment （P 〈0.01） ; There were no significant differences in the HAMA scores and clinical effect of two groups after 6- week treatment （P 〉 0.05） ; Biofeedback group were lower in the drug dosage （P 〈 0.05） . Conclusions Combined therapy and drug treatment are good therapy in the treatment of anxiety disorder. Biofeedback plus sertraline had better effect than sertraline treatment, which can shorten course of treatment and decrease medical expenses.