单扫描示波极谱法测定非那雄胺

Determination of Finasteride by Single-Sweeping Oscillopolarography

在0.01 mol·L^-1 HCl-2.5×10^-5mol·L^-1十二烷基三甲基氯化铵-水-乙醇溶液（21＋4）底液中,采用单扫描示波极谱法测定,非那雄胺在-1.27 V（vs.SCE）处有一灵敏的极谱还原波。二阶导数峰电流I″p与非那雄胺浓度在1.0～10.0 mg.L-1范围内呈线性关系,相关系数为0.999 6（n=6）,检出限为0.2 mg·L^-1。连续11次平行测定2.0 mg·L^-1非那雄胺还原波峰电流,相对标准偏差为1.3%。此方法用于片剂中非那雄胺含量的测定,其回收率在99.7%～105.2%之间。

In a mixed base solution of 0. 01 mol · L^-1 HCl and 2. 5 × 10^-5 mol · L^-1 dodecyl-trimethyl ammonium chloride in aqueous ethanol solution （H2O＋C2H5OH= 21 ＋4）, a sensitive reduction wave was given by finasteride with its peak potential at -1. 27 V （vs. SCE） by single sweeping oscillopolarography. Linear relationship between the 2nd derivative of peak current （I″p） of the reduction wave and the concentration of finasteride was obtained in the range of 1.0-10. 0 mg of finasteride per L of solution （r= 0. 999 6）, with a detection limit of 0. 2 rng · L^-1. The RSD＇s found when tested at the concentration level of 2. 0 mg ·L^-1 was 1.3% （n=11）. The proposed method has been applied to the analysis of finasteride tablet samples, giving recoveries in the range of 99. 7%-105. 2%.