血清BLyS和APRIL水平与系统性红斑狼疮关联性研究

Study on Relationship of Serum BLyS and APRIL Levels and Systemic Lupus Erythematosus

目的:探讨系统性红斑狼疮(SLE)患者血清B淋巴细胞刺激因子(BLyS)和增殖诱导配体(APRIL)蛋白水平与疾病活动性的关系。方法:应用酶联免疫吸附试验(ELISA)法检测SLE活动组(13例)和SLE缓解组(10例)患者血清BLyS和APRIL水平,以健康志愿者(23例)作为对照;同时将血清BLyS和APRIL水平与患者的临床检验指标(尿蛋白、抗dsDNA抗体)分组进行分析。结果:SLE患者组血清BLyS水平高于健康对照组,且活动期高于缓解期(P<0.05);尿蛋白阳性组血清APRIL水平明显低于尿蛋白阴性组患者(P<0.05);抗dsDNA抗体升高组血清BLyS和APRIL均高于抗dsDNA抗体滴度正常组,但均无统计学意义。结论:SLE患者血清BLyS水平增高,且增高与疾病的活动性有关;尿蛋白阳性组血清APRIL水平明显低于尿蛋白阴性组SLE患者,提示BLyS和APRIL可能参与SLE的发病过程。

Objective：To determine serum BLyS and APRIL levels of patients with systemic lupus erythematosus （SLE）, and investigate the relationship between serum BLyS and APRIL level and SLE disease activity. Methods：To measure serum BLyS and APRIL levels with ELISA in patients with SLE, who were separated into active group （n = 13） and remission group （n = 10） according to the SLE disease activity index（SLEDAI） and 23 healthy Volunteers and analyze the relationship among serum BLyS and APRIL levels and several clinical items（such as protinuria and anti-dsDNA antibody）. Results ：Serum BLyS levels in patients with SLE was significantly elevated compared to healthy Controls （P〈0.05）, and active group was higher than remission group（P〈0. 05）; The patients with elevated proteinuria had reduced serum APRIL levels （P〈0.05）; The patients with elevated anti-dsDNA antibody had enhanced serum BLyS and APRIL levels, but its was of no statistics significance （P〉0. 05）. Conclusion：Serum BLyS levels is positively related to disease activity; The patients with elevated proteinuria have reduced serum APRIL levels （P〈0. 05）. BLyS and APRIL may be involved in the pathogenesis of SLE.