缺氧诱导因子-1α与脑缺氧缺血性损伤

Hypoxic-Inducible Factor-1α and Cerebral Hypoxic/Ischemic Injury

缺氧诱导因子-1α(hypoxia-inducible factor-1 alpha,HIF-lα)是近来发现的广泛存在于哺乳动物和人体内的一种缺氧应答调控因子,在调节缺氧诱导的基因表达中起关键性作用。它可调节表达多种靶基因如血管内皮生长因子、促红细胞生成素等,对改善脑缺氧缺血后能量代谢障碍、促进脑血流动力学恢复、抑制兴奋性氨基酸毒性、减少细胞凋亡等起重要作用。通过进一步对HIF-lα及其靶基因的研究,可能为临床治疗脑缺氧缺血性损伤提供了一种新的治疗策略。

Hypoxia-inducible factor-lα（ HIF-lα） is a recently identified hypoxia responding regulation factor, which exists in mammals and humans. It plays a key role in the regulation of hypoxia-mediated gene expression. It can regulate many target genes＇ expression, such as vascular endothelial growth factor and erythropoietin. The action of HIF-lα may be attributed to its improving energy metabolism after cerebral hypoxia/ischemia, promoting cerebral hemodynamics, inhibiting excitatory amino acids toxicity, and reducing apoptosis. Further investigation of the expression and action profiles of HIF-lα and its target genes may lead to a new therapy strategy for cerebral hypoxia/ischemia injury.