摘要
以空心多孔纳米SiO2为缓释载体，利用超临界包埋法、结合球磨分散与喷雾干燥等工艺制备了具有缓释和防止紫外光降解双重特性的阿维菌素纳米缓释粉剂。液相色谱分析表明阿维菌素在制剂的制备前后性质未发生变化。所制缓释粉剂经水分散后粒径约为200-500 nm，分布均匀。悬浮稳定性和热贮稳定性均符合国家农药制剂标准。未制剂化的载药微球因微囊团聚严重，药物释放过程阻力大，药物累积释放大概1400 min后仅达60%；而缓释粉剂在溶出的前5 min即释放70%，具有迅速灭杀害虫效果，而剩余的农药以较为平缓的速率释放，在100 min后累积释药80%，并且可以受到载体的保护而不受紫外光降解影响。
A sustained-release nano powder formulation for avermectin has been prepared from porous hollow silica nanoparticles by supercritical fluid drug loading, milling and spray drying. HPLC spectra indicated that the properties of avermectin were not affected by the formulation process, The mean diameter of the formulated powders after being re-dispersed in water was in the range of 200 - 500 nm, demonstrating the high water dispersibility of this formulation. The storage stability meets the requirements of the National Pesticide Formulation Standards. Furthermore, the formulation shows an excellent sustained-release pattern and, in addition, the carrier protects the entrapped avermectin against UV degradation.
出处
《北京化工大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第4期337-340,共4页
Journal of Beijing University of Chemical Technology(Natural Science Edition)
基金
国家自然科学基金(20506001/20325621)
教育部新世纪优秀人才支持计划(NCET-04-0123)
北京市教委资助项目(JD100100403)
关键词
纳米SIO2
缓释剂
粉剂
阿维菌素
silica nanoparticles
sustained-release
powder formulation
avermectin
