摘要
目的:考察注射用加替沙星与注射用法莫替丁在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法:在(20±1)℃条件下,分别观察及测定8h内配伍液的外观、pH值及紫外光谱的变化,并用紫外分光光度法测定加替沙星和法莫替丁的含量。结果:2药配伍后,8h内的pH值及含量均无明显变化;另在0.9%氯化钠注射液中8h内与5%葡萄糖注射液中6h内,配伍液的外观无明显变化。结论:注射用加替沙星与注射用法莫替丁在0.9%氯化钠注射液和5%葡萄糖注射液中配伍稳定。
OBJECTIVE: To study the compatibility of gatifloxacin for injection with famotidine for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS:At room temperature ((20 ± 1)℃ )for 8 hours, the changes of the mixture in appearance,pH and UV spectra were observed,and the contents of gatifloxacin and famotidine were determined by ultraviolet spectrophotometry.RESULTS:No significant change was found in pH values and contents within 8h after mixing of the two drugs,nor significant changes were found for the mixture in appearance within 8h in 0.9% sodium chloride injection or within 6h in 5% glucose injection.CONCLUSION: The mixture of gatifloxacin for injection and famotidine for injection were stable in 0.9% sodium chloride injection or 5% glucose injection.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第20期1563-1565,共3页
China Pharmacy
基金
河北省2004年医学科学研究重点课题(04177)
关键词
注射用加替沙星
注射用法莫替丁
配伍
稳定性
紫外分光光度法
Gatifloxacin for injection
Famotidine for injection
Compatibility
Stability
UV spectrophotometry