水溶性meso-四(4-氯-3-磺酸钠苯基)卟啉合成的改进

Synthesis of meso-tetra(4-chlorol-3-sulfophenyl) Porphyrin

以非水溶性卟啉为原料合成水溶性卟啉meso-四（4-氯-3-磺酸钠苯基）卟啉,氯仿作溶剂,氯磺酸作为磺化试剂,与meso-四（4-氯苯基）卟啉反应,并确定其最佳反应条件为n（卟啉）∶n（氯磺酸）=1.33∶29.80,氯仿15 mL,温度60℃,反应时间2 h.该法较传统磺化方法反应温度低60～80℃且易于控制,不产生粘稠状的副产物,产物易于分离纯化,产率达11.4%.

The synthesis of water-soluble meso-tetra（4-chlorol-3-sulfophenyl） porphyrin used by water-insoluble meso-tetra（4-chlorol phenyl）porphyrin is reported using CHC13 as solvent and ClSO3H as sulfated reagent. The experimental results show the best ratio of reactant is n （ meso-tetra （4- chlorol -3- sulfophenyl） porphyrin）： n （ClSO3H）：= 1.33：29.80, CHCl3 is 15 mL, the reactive time is 2 h at 60℃. In this technology, the temperature is 60--80℃ lower than traditional method and the reaction is controlled more easily, the yield is 11.4 %.