17β-羟类固醇脱氢酶与子宫内膜异位症的关系

Relationship between 17β-Hydroxysteroid Dehydrogenase and Endometriosis

目的探讨17β-羟类固醇脱氢酶2(17βHSD2)在子宫内膜异位症(内异症)在位与异位内膜的表达与发病的关系。方法采集因内异症和宫颈上皮内瘤样病变行子宫切除的分泌晚期子宫内膜,分别为内异症组和对照组研究标本。RT-PCR检测两组在位子宫内膜与卵巢巧克力囊肿17βHSD2 mRNA表达。结果内异症组28例,对照组15例在位内膜17βHSD2 mRNA呈阳性表达,两组在位内膜17βHSD2 mRNA表达情况间差异无显著性意义(P>0.05);28例卵巢巧克力囊肿17βHSD2 mRNA全部呈阴性表达,与配对在位内膜比较差异有显著性意义(P<0.05)。结论内异症患者异位内膜缺乏17βHSD2与内异症发病有关。

Objective To investigate the expression of 17βhydroxysteroid dehydrogenase type 2 （17βHSD2） in the eutopic endometrium and endometriotic tissue of endometriosis. Methods Eutopic endometrium were obtained from the operated patients with endometriosis and the control （patients with cervical cancer in situ）, 17βHSD2 was examined by RT- PCR. Results 17βHSD2 were expressed positively in eutopic endometrium of endometriosis （ n = 28 ） and control （ n = 15 ）. There was no significant difference in level of 17βHSD2 beteewn the two groups （ P 〉0.05）. 17βHSD2 were expressed negatively in ovarian endometfiotic tissue and there was significant difference in the level of 17βHSD2 compared with its eutopic endometrium （ P 〈 0. 05 ）, Conclusion The absence of 17βHSD2 in endometriotic tissue may be associated with endometriosis.