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CDKN2A基因变异与肿瘤 被引量：4

The alterations of CDKN2A gene and tumor
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摘要 细胞周期依赖性激酶抑制基因(CDKN2A)为抑癌基因,编码两种周期抑制蛋白p16INK4a和p14ARF;进而通过p16INK4a-CDK4(和CDK6)-pRb途径和p14ARF-mdm2-p53途径发挥细胞周期调控作用。研究发现在多种肿瘤中均存在CDKN2A的基因变异,现就近年来的研究状况做一简要概述。 Cyelin - dependent kinase inhibitor （CDKN2A） is an important tumor suppressor gene, whieh belongs to eyelin - dependent kinase inhibitor family. It plays a eritieal role in regulating eell proliferatin and apoptosis. CDKN2A gene is also ealled INK4a -ARF gene, and it eneodes two proteins named as pl6INK4a and pl4ARF whieh aetions by Rb and p53 respeetively. Researchers pay more attention to its role in tumorigenesis because of its alterations in various tumors.
作者 王静 张小为
机构地区 北京大学第三医院妇产科
出处 《中国优生与遗传杂志》 2007年第7期114-116,共3页 Chinese Journal of Birth Health & Heredity
关键词 肿瘤 CDKN2A 基因变异 Tumor CDKN2A Gene alteration
分类号 R730.2 [医药卫生—肿瘤]
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参考文献20

  • 1Stott FJ,Bates S,James MC,et al.The alternative product from the human CDKN2A locus,p14(ARF),participates in a regulatory feedback loop with p53 and MDM2[J].EMBO J,1998,17:5001-14.
  • 2Pineau P,Marchio A,Cordina E,et al.Homozygous deletions scanning in tumor cell lines detects previously unsuspected loci[J].Int J Cancer,2003,106:216-23.
  • 3Petty EM,Gibson LH,Fountain JW,et al.Molecular definition of a chromosome 9p21 germ-line deletion in a woman with multiple melanomas and a plexiform neurofibroma:implications for 9p tumor-suppressor gene(s)[J].Am J Hum Genet,1993,53:96-104.
  • 4Grafstrom E,Egyhazi S,Ringborg U,et al.Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival[J].Clin Cancer Res,2005,11:2991-7.
  • 5Chang LL,Yeh WT,Yang SY,et al.Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer[J].J Urol,2003,170:595-600.
  • 6Chapman EJ,Harnden P,Chambers P,et al.Comprehensive analysis of CDKN2A status in microdissected urothelial cell carcinoma reveals potential haploinsufficiency,a high frequency of homozygous co-deletion and associations with clinical phenotype[J].Clin Cancer Res,2005,11:5740-7.
  • 7Attri J,Srinivasan R,Majumdar S,et al.Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma[J].BMC Gastroenterol,2005,5:22.
  • 8Li J,Weghorst CM,Tsutsumi M,et al.Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors[J].Carcinogenesis,2004,25:263-8.
  • 9Zhao GH,Li TC,Shi LH,et al.Relationship between inactivation of p16 gene and gastric carcinoma[J].World J Gastroenterol,2003,9:905-9.
  • 10Park JS,Dong SM,Kim HS,et al.Detection of p16 gene alteration in cervical cancer using tissue microdissection and LOH study[J].Cancer Lett,1999,136:101-8.

二级参考文献20

  • 1Reed AL,Califanao J,Cairns P,et al.High frequency of p16 (CDKN2/ MTS1/INK4A) inactivation in head and neck squamous cell carcinoma . Cancer Res, 1996,56∶3630-3633.
  • 2Roesler JM,Livingston EH,Srivatsan E,et al.Deletion of p15(MTS2) in head and neck squamous cell carcinomas. J Surg Res,1998,77∶50-54.
  • 3Gongalez MV,Pello MF,Lopez-Larrea C,et al.Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma.J Clin Pathol, 1997,50∶509-512.
  • 4Duro D,Bernard O,Valle VD,et al.Inactivation of p16INK4/MTS1 gene by a chromosome translocation t(9;14)(p21-22;q11) in all of B-cell type. Cancer Res, 1996,54∶848-854.
  • 5Kamb A,Gruis NA,Weaver-Feldhaus J,et al.A cell cycle regulator potentially involved in genesis of many tumor types. Science,1994,264∶436-440.
  • 6Serrano M,Hannon GJ,Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.Nature,1993,366∶704-707.
  • 7Guan KL,Jenkins CW,Li Y,et al.Growth suppression by p18,a p16INK4/MTS1 and p15INK4B/MTS2 related CDK6 inhibitor,correlates with wild-type pRB function. Genes Dev,1994,8∶2939-2952.
  • 8Hannon GJ,Beach D.p15INK4B is a potential effector of TGF-β induced cell cycle arrest.Nature,1994,371∶257-261.
  • 9Nobori T,Miura K,Wu DJ,et al.A deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.Nature,1994,368∶753-756.
  • 10Hirabayashi H,Fujii S,Sakaguchi M,et al.p16INK4,pRB,p53 and cyclinD1 expression and hypermethylation of CDKN2 gene in thymoma and thymic carcinoma. Int J Cancer,1997,73∶639-644.

共引文献4

同被引文献31

  • 1阚卫兵,方肇勤,耿琳.CDKN2A研究进展[J].国外医学（肿瘤学分册）,2004,31(7):483-486. 被引量：2
  • 2张军平,张伯礼,山本清高.中药药物血清的制作方法探讨[J].天津中医药,2004,21(4):274-276. 被引量：41
  • 3张吉才,余宗涛,吕军,李海平,冯景,吴健民,胡丽华.HBV感染与肝癌组织CDKN2A基因甲基化关系的研究[J].中华肿瘤防治杂志,2006,13(12):892-895. 被引量：7
  • 4King H, Aubert R E, Herman W H. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care, 1998,21 : 1414-1431.
  • 5Rodriguez I, Coto E, Reguero J R, et al. Role of the CDKN1A/ p21, CDKN1C/p57, and CDKN2A/p16 genes in the risk of atherosclerosis and myocardial infarction. Cell Cycle, 2007, 6: 620-625.
  • 6Dzau V J, Braun-Dullaeus R C, Sedding D G. Vascular proliferation and atheroselerosis: new perspectives and therapeutic strategies. Nat Med,2002,8:1249-1256.
  • 7Andres V. Control of vascular cell proliferation and migration by cyclin-dependent kinase signalling: new perspectives and therapeutic potential. Cardiovasc Res, 2004,63:11-21.
  • 8Helgadottir A, Thorleifsson G, Manolescu A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science, 2007,316 : 1491-1493.
  • 9Abe J, Zhou W, Taguchi J, et al. Suppression of neointimal smooth muscle cell accumulation in vivo by antisense cdc2 and cdk2 oligonucleotides in rat carotid artery. Biochem Biophys Res Commun, 1994,198 : 16-24.
  • 10Ihling C, Technau K, Gross V, et al. Concordant upregulation of type II-TGF-beta-reeeptor, the eyclin-dependent kinases inhibitor P27Kipl and cyclin E in human atherosclerotic tissue: implica tions for lesion cellularity. Atherosclerosis,1999,144:7 -14.

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中国优生与遗传杂志
2007年 第7期

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