5-HT2c受体基因cys23ser多态性与单相抑郁症的相关性

Analysis on the relationship among 5-HT2c receptor gene T371 G polymorphism, unipolar depression and symptom phenotype

目的探讨5-HT2c受体基因cys23ser多态性与单相抑郁症及其症状群的遗传关联性，搜寻中国汉族人单相抑郁症可能的易感性基因。方法应用聚合酶链式反应扩增技术与限制性片断长度多态性分析技术（PCR-RFLP），对132例单相抑郁症患者和180名正常对照者进行关联分析；采用汉密顿抑郁量表（HAMD）评定病例组症状群，分析单相抑郁症症状群与基因型的关联性。结果病例组与对照组的基因型总体分布差异有显著性（χ^2=7．089，P=0．029），但进一步按性别分层分布差异无显著性（女性：χ^2=1．891，P=0．389；男性：χ^2=0．879，P=0．348）；病例组HAMD各因子评分基因型分布差异无显著性（P〉0．05）。结论 5-HT2c受体基因cys23ser多态性可能与中国汉族人单相抑郁症有关联。

Objective To investigate the association between 5-HT2c receptor gene cys23ser polymorphism and unipolar depression（UPD） in Han nationality of Chinese. Methods The ease-control association study was adopted to analyze association of the four candidate serotonin receptor genes polymorphism between 132 UPD patients and 180 normal controls using the polymerase chain reaction and restriction fragment length polymorphisms （PCR-RFLP） technique, and evaluate the symptom phenotypes of cases applying the Hamilton Rating Scale for Depression （HAMD）. Results There were significant difference in genotypes distribution between case group and control group （ χ^2 = 7. 089, P = 0. 029 ）, however, there were no significant in different sex, respectively （ female ：χ^2 = 1. 891, P = 0. 389 ; male ： X^2 = 0. 879, P = 0.348 ）. The genotypes distributions in HAMD factors were no significant difference in case group （ P〉 0.05）. Conclusion The polymorphism of 5-HT2c receptor gene cys23ser might be related with Han UPD.