新型蛋白酪氨酸激酶抑制剂类抗肿瘤药物的研究进展

Progress of research on the new protein tyrosine kinase inhibitor antitumor drugs

目的探讨蛋白酪氨酸激酶抑制剂抗肿瘤作用机理及其研究进展。方法综述了最新发现的小分子酪氨酸激酶抑制剂的化学结构、抗肿瘤作用及其作用机制及其发展方向等内容。结果结论蛋白酪氨酸激酶与细胞的增殖、分化、迁移和凋亡有着密切的关系,在细胞生命活动的信号转导途径中扮演着十分关键的角色,筛选酪氨酸激酶抑制剂已经成为开发抗肿瘤药物的新途径。

Objective To approach the mechanism of action of anticancer and the investigation progress of protein tyrosine kinase （PTK）. Methods This article reviewed some new tyrosine kinase inhibitors （TKI） about their chemical structures, anticancer-effect; mechanism of action and development. Results and Conclusions Protein tyrosine kinase （PTK） plays very important role in cellular multiplication, differentiation, immigration and apoptosis closely, which acts as an important role in the cellular significance signal transduction pathway. So screening of tyrosine kinase inhibitor （TKI） has become a new channel to exploit new anti-cancer drugs.