高能聚焦超声治疗对原发性胰腺癌患者免疫功能的影响

Effects of high intensity focused ultrasound treatment on immune function in patients with pancreatic carcinoma

目的观察高能聚焦超声(HIFU)治疗后,原发性胰腺癌患者的免疫功能变化。方法应用FEP-BY01型肿瘤超声治疗机对46例原发性胰腺癌患者进行治疗,分别取HIFU治疗前和治疗后4周外周血10ml,检测T细胞亚群:CD4、CD8、CD4/CD8;Th细胞因子;γ干扰素(IFN-γ)、白细胞介素2(IL-2)、IL-4、IL-10。结果46例胰腺癌患者治疗后CD4T细胞百分数、CD4/CD8比值较治疗前明显升高,而CD8T细胞百分数下降;治疗后IL-2、IFN-γ含量较治疗前明显升高,而IL-4、IL-10含量较治疗前明显下降。结论应用HIFU技术治疗原发性胰腺癌可以改善患者体内的细胞免疫功能。

Objective To study the changes of immune function of patients with pancreatic carcinoma after high intensity focused ultrasound （HIFU） treatment. Methods Forty-six patients with pancreatic carcinoma were treated by HIFU. T-lymphocyte subsets CD4, CD8, CD4/CD8 and cytokines IFN-γ,IL-2,IL-4,IL-10 in 10 ml of peripheral venous blood were examined before and four weeks after HIFU treatment. Results The posttreatment levels of CD4, CD4/CD8, IFN-γ and IL-2 were much higher than those before treatment. Whereas the levels of CD8, IL-4 and IL-10 were significantly lower than those before treatment. Conehtsion HIFU treatment of the patients with pancreatic carcinoma may improve the immune function by promoting the recovery of T-lymphocyte subsets and Thl/Th2 cytokine levels from imbalance.