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CXCL12-CXCR4轴与乳腺癌转移研究进展 被引量：1

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摘要 “归巢”理论认为乳腺癌的转移是一个主动、有序、有器官选择性的过程,其中特异性趋化因子受体4(CXCR4)和趋化因子配体12(CXCL12)所构成的生物学轴在乳腺癌器官特异性转移中发挥重要作用,本文就该轴与乳腺癌转移的临床试验和动物实验研究及其发挥作用机理的研究进展作一综述。
作者 花永强 刘胜 谭松
机构地区 上海中医药大学中医外科研究所
出处 《江苏医药》 CAS CSCD 北大核心 2007年第7期726-727,共2页 Jiangsu Medical Journal
基金 国家自然科学基金(30572393) 上海市中医外科重点学科建设基金(T0304)
关键词 乳腺癌转移 器官特异性转移 趋化因子配体 趋化因子受体 器官选择性 生物学轴 实验研究 临床试验
分类号 R737.9 [医药卫生—肿瘤]
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参考文献18

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同被引文献10

  • 1Mundy GR. Metastasis to bone: causes consequences and therapeutic opportunities[J]. Nat RevCancer, 2002,2(8): 584-593.
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  • 3Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties[J]. Cancer Res, 2005,65 (13) : 5506- 5511.
  • 4Kim HJ,Lee HJ,Kwon SY,et al. The prevalence of pulmontary parenchymal tuberculosis in patients with tuberculous pleuritis[J]. Chest,2006,129(3) :1253-1258.
  • 5Draffin JE, McFarlane S, Hill A, et al. CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells[J]. Cancer Res,2004,64(16) : 5702-5711.
  • 6Sheridn C, Kishimoto H, Fuchs RK, et al. CD44^+/CD24^- breast cancer cells exhibit enhanced invalsive properties: an early step necessary for metastasis[J]. Breast Cancer Res, 2006,8 (6) :59-62.
  • 7Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis[J]. Nature, 2001,410 (6824) :50-56.
  • 8Kang Y,Siegel PM,Shu W,et al. A multigenic program mediating breast cancer metastasis [J]. Cancer cell, 2003,3 (6) : 537-549.
  • 9Liang Z, Wu T, Lou H, et al. Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4 [J]. Caneer Res,2004,64(12):4302-4308.
  • 10刘晓,范萍,王水,武正炎.小鼠人乳腺癌自发性肺转移模型的建立[J].中华实验外科杂志,2003,20(7):661-662. 被引量：9

引证文献1

江苏医药
2007年 第7期

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