儿童供、受体ABO血型不相容肝移植免疫抑制治疗进展

The progress of immunosuppression in pediatric ABO incompatible liver transplantation

随着国内供体池越来越紧缺，ABO血型不相容肝移植成为急症肝移植的选择之一。文献报道儿童ABO血型不相容肝移植效果好于成人。而ABO血型不相容儿童肝移植的免疫治疗发展，也反映了免疫治疗的发展。随着新型免疫抑制药物的出现，为了减少过度免疫抑制带来的副作用，人们提出了更多更有效的免疫抑制方案，使得跨血型屏障的急症儿童肝移植获得较好的效果。

Following the shortage of liver donor pool, ABO incompatible liver transplantation has become necessary selection. Some reports suggest the result of pediatric ABO incompatible liver transplantation better than adults. Immunosuppressive therapy for ABO-incompatible pediatric liver transplant is evolving towards minimization, reflecting a general tendency in organ transplantation. With the availability of newer drugs, however, more selective strategies have been proposed in these recipients in order to limit the side effects related to excessive immunosuppression.