2,4,6-三芳基吡啶的微波辐射促进合成

Synthesis of 2,4,6-Triarylpyridines Under Microwave Irradiation

在醋酸铵和醋酸体系中,利用微波辐射,研究了氯化N-苯乙酮基吡啶和查尔酮反应,以较高产率得到2,4,6-三芳基吡啶衍生物5a^5g(67%~90%)。研究了氯化N-苯乙酮基吡啶直接与芳醛和取代苯乙酮一锅煮反应,可以得到高产率地2,4,6-三芳基吡啶衍生物5h^5i(77%~84%)。化合物的结构均用1H NMR、IR测试技术进行了表征。

Under microwave irradiation, N-phenacylpyridinium chloride 1 reacted with chalcone 2 in the presence of ammonium acetate to afford 2,4,6-triarylpyrididnes 5a -5h in high yields. 2,4,6-Triarylpyridines 5a - 5h can also be prepared from the one-pot reaction of N-phenacylpyridinium chloride with each of aromatic aldehydes 3 and each of substituted acetophenones 4. The products were identified by ^1H NMR and IR spectroscopy.