雷公藤多甙与新鲜血浆联合应用治疗复合物型肾小球肾炎实验研究

Experimental Study of Therapeutic Effect of GTW Administration and Fresh Plasma Transfusion on ICGN

通过家兔急性实验性血清病模型和临床慢性肾小球肾炎（ＧＮ）病人探讨了雷公藤多甙（ＣＴＷ）加输新鲜血浆治疗ＧＮ疗效观察。模型组家兔与临床病人所得实验结果基本相同。治疗后血清循环免疫复合物水平显著下降。补体溶解免疫复合物后性水平明显上升，与未治疗组相比．差异显著，Ｐ＜０．０１。ＧＮ病人治疗后ＣＤ＿３、ＣＤ＿８Ｔ细胞无变化，ＣＤ＿１明显下降，Ｐ＜０．０１。ＣＤ＿１／ＣＤ＿８比值由常规疗法的２．１２下降到１．３３。细胞因子治疗后。ＩＬ－８、ｓＩＬ－２Ｒ、ＩＬ－２、ＩＦＮ和ＴＮＦ均明显下降，与未治疗组相比．差异显著，Ｐ＜０．１。肾脏病理损伤程度与未治疗组相比明显减轻。从本实验结果看出，雷公藤多甙加输新鲜血浆治疗ＧＮ是有效的。

This paper repctrs immunopathogenesis of GN and therapeutical effect of GTW ad- ministration and fresh plasma transfusion The experimental results showed that leveis of CIC ,sIL- 2R , IL-8 , and the activity of IL-2 , TNF and IFN were increased significantly , while CMSC was de- creased markedly in model rabbits with AESSR. CD_3 、CD_4 cells and mlL-2R (CD-25 ) also dwindled markedly in patiencs with GN. After treatment the CIC , sll-2R , II-8 , TNF and IFN levels were de- creased , while CMSC was increased obviously. The pathological damages of the renal tissue was lcss- ened subsequetly. Thus authors belived that GTW admistratration and fresh plasrma transfusion therapy has markedly effect.