碳纳米管碳糊电极吸附伏安法测定西沙必利

Adsorptive Voltammetric Determination of Cisapride on Carbon Nanotubes Paste Electrode

用循环伏安法和差分脉冲伏安法研究了西沙必利在多壁碳纳米管碳糊电极上的伏安行为和反应机理。在pH6．09 Britton-Robinson缓冲液中，西沙必利在＋0．89V（vs．SCE）处产生一灵敏的氧化峰。该氧化峰是由吸附控制的两电子一质子不可逆过程。其峰电流与浓度在4．0×10^-8～2．0×10^-5mol／L范围内呈线性关系（r=0．997），检出限为1．0×10^-8mol／L。对5×10^-6mol／L西沙必利平行测定10次的相对标准偏差为3．68％。用本法测定了片剂中西沙必利的含量，加标回收率为94．0％-104％。

The vohammetric behavior and electrochemical reaction mechanism of cisapride on carbon nanotubes paste electrode（CNTPE） has been investigated using cyclic and differential pulse vohammetry. In pH 6.09 Britton-Robinson buffer,cisapride produced a sensitive oxidation peak at ＋0.89 V （vs. SCE）. The oxidation of eisapride was an adsorption-controlled irreversible two-electron and one-proton process. The peak current varied linearly with the concentration of eisapride in the range from 4.0 × 10^-8 to 2.0 × 10^-5 mol/L. The detection limit was 1.0 × 10^8 mol/L. The relative standard deviation （RSD） of ten measurements was 3.68% for 2.0 × 10^-6 mol/L cisapride. The proposed cisapride tablets.