用PCR研究干扰素对宫颈糜烂患者人乳头瘤病毒感染的疗效

DETECTION WITH PCR OF HUMAN PAPILLOMAVIRUS DNA IN CERVICAL EROSION TREATED WITH INTRFERON

对３７例宫颈糜烂患者用干扰素治疗后发现，治疗前ＰＣＲ检测ＨＰＶ阴性的８人治疗显效率和有效率分别为１２．５％和８７．５％，治疗前ＨＰＶ阳性的２９人治疗显效率和有效率则达６９．０％和９３．１％，ＨＰＶ阴转率达８９．７％。该结果表明ＨＰＶ对ＩＦＮ十分敏感，局部ＩＦＮ治疗ＨＰＶ引起的宫颈糜烂，方法简便有效。

After one course of interferon therapy,markedly improved rate and improved rate was 12 5% and 87 5% seperatedly in 8 patients who wrer HPV negative by PCR detection before treatment while in 29 patients who wrer HPV positive before treatment was 69 0% and 93 1% respectively.89 7%(26/29) patients became HPV negative after treatment.The results indicated the HPV was very sensitive to IFN.Topic IFN application to those patients with cervical erosion saused by HPV was a simple and effective method.