T细胞亚群的检测在肾移值术后急性排斥反应时的临床意义

THE SIGNIFICANCE OF T LYMPHOCYTE SUBPOPULATIONS DETECTING IN PATIENTS WITH ACUTE REJECTION FOLLOWING RENAL TRANSPLANTATION

通过流式细胞仪对５４例肾移植术后受者外周血Ｔ细胞亚群进行动态监测。结果显示肾移植术后发生急性排斥反应时，ＣＤ３＋、ＣＤ４＋细胞及ＣＤ４＋／ＣＤ８＋比值均升高，经激素冲击治疗有效的病人ＣＤ３＋、ＣＤ４＋细胞及ＣＤ４＋／ＣＤ８＋比值逐渐下降，而ＣＤ３＋、ＣＤ４＋细胞及ＣＤ４＋／ＣＤ８＋比值居高不降者说明激素冲击冶疗无效。Ｔ细胞亚群检测可作为对肾移植术后急性排斥反应进行监测的一种方法。

The flowcytometer was used to study the changes of T lymphocyte subsets in peripheral blood from 54 patients following renal transplantation.The results showed that when the acute rejection was occurrence,the CD3 +、CD4 + subsets and CD4 +/CD8 + were increased.After elective anti rejection therapy the CD3 +、CD4 + subsets and CD4 +/CD8 + ratio were decreased to normal.If they did not decreased,the ineffects of the therapy was indicated.