胰岛素样生长因子(IGFs)及其在早期胚胎发育中的作用

Insulin-like growth factors (IGFs) and their effects on early embryo development

胰岛素样生长因子(IGFs)在哺乳动物的生长发育过程中通过受体介导对生物体的生长起重要的调节作用。其在早期的胚胎发育过程中,对胚胎的生长发育十分重要。IGFs通过与IGFBPs家族蛋白的结合调节早期胚胎发育过程中的细胞凋亡。IGF-1可以增加体外培养的胚胎的囊胚发育率,并与其它基因协同作用调节胚胎细胞的凋亡,但其确切的抗凋亡的分子机理目前仍在研究中。

During the course of mammalian development, insulin-like growth factors（IGFs） play important roles to regulate mammal growth by combining their receptors. IGFs are also very important on embryonic cell proliferation and differentiation during early embryo development. In this course, IGFs combine with IGFBPs to regulate apoptosis. IGF-1 can increase the ratio of blastulation in vitro and regulate apoptosis cooperation with other genes. The mechanism of the anti-apoptosis function of IGF-1 still be in investigation.