涎腺肌上皮癌的生物学行为及治疗

The behaviour and treatment of myoepithelial carcinoma of salivary glands

为了总结涎腺肌上皮癌的生物学行为及有效治疗，作者对１９例涎腺肌上皮癌患者进行临床分析，其临床特点为：发病部位以腮腺为最常见，其次为腭部；部分肿瘤生长迅速，广泛侵犯周围组织；颈部淋巴结转移率不很高，但血行性转移率高；治疗后极易复发；患者预后差。其生物学行为属高度恶性肿瘤。治疗以根治性切除为主，原则上不作选择性颈淋巴清扫术；放射治疗不敏感。对于局限性肿瘤复发灶及时手术可获得较好的效果。

Nineteen cases of myoepithelial carcinoma (malignant myoepithelioma) in salivary glands were studied clinicopathologically. The clinical features are as follows: arise most frequently within the parotid glands, followed by the submandibular glands; rapidly enlarging mass with extensive invasion of the surrounding tissues in some cases; low rate of cervical lymph node metastasis but high rate of distant metastasis; very frequent recurrence after surgical excision; and poor prognosis. The carcinoma belongs to the high grade malignant tumor. It must be treated radically. The elective neck dissection is generally unnecessary. It is resistant to radiotherapy. It is possible to get rather good result in limited recurrent tumors by prompt surgery.