肿瘤局部湿热治疗乳腺癌实验动物模型的建立及意义

Significance of Experimental Animal Model of Mouse Mammary Carcinoma in Local Wet Hyperthermia

目的:探讨局部湿热治疗对肿瘤生长的影响及意义。方法:建立Balb/c乳腺癌4T1实验动物模型,并以不同温度和作用时间对肿瘤进行局部湿热处理。结果:结果发现43℃作用35min,每周1次,局部湿热治疗可有效控制肿瘤生长,减少肺转移的发生。结论:局部湿热治疗可以有效抑制肿瘤生长,具有潜在的临床推广应用价值。

Objective： To explore the significance and effects of local wet hyperthermia on tumor growth. Method： Establish experimental animal model of mouse mammary carcinoma and treat animal model at different temperature for different heating time. Results： Local wet hyperthermia at 43 degree, once a week and lasting for 35 minutes, can inhibit the tumor growth and reduce the lung metastasis of tumor on ani real model. Conclusions： Local wet hyperthermia could influence tumor growth and own potential value of clinical application.