原发性肝癌的免疫状态及其过继免疫治疗

Immunologic Status of the Patients with Primary Hepatocellular Carcinoma Treated by Adoptive Immunotherapy

1993年3月～1995年12月，20例无手术切除指征的肝癌患者接受rIL－2／LAK过继免疫治疗，其中6例（30％）获部分缓解。16例肝癌患者于治疗前后行免疫功能测定，结果显示：1）原发性肝癌病人外周T细胞亚群及NK活性是明显抑制状态（P＜0．001）；2）患者经过过继免疫治疗后，T细胞工群及NK细胞活性明显改善。上述结果表明原发性肝癌病人是明显免疫抑制状态，采用rIL－2／LAK区域过继免疫治疗有效。

From March 1993 to December 1995,twenty patients with unresectable hepatocellular carcinoma (HCC ) received local adoptive immunotherapy (rIL-2/LAK ). Of these, six (30 % ) had partial response. Immunological responses were assessed in 16 patients with HCC before and one month after immunotherapy.The results were as follows: 1 )T cell subsets and NK activity of peripheral blood in patients with HCC were significantly suppressed (P < 0. 001 ). 2 ) After immunotherapy, the number and activities of T cells and NK cells were remarkably improved. These results suggest that HCC patients are under marked immunosuppresslve condition and local adoptive immunotherapy would benefit.