LAK细胞及rIL-2腹腔灌注对胃癌术后预防腹膜转移的研究

Intraperitoneal Instillation of LAK Cells and rIL-2 in Prevention of Peritoneal Metastasis after Surgery for Gastric Cancer

作者选用3组Ⅲ期胃癌病例，即根治术后用LAK细胞／rIL－2腹腔灌注的LAK组，用5－Fu腹腔灌注的5-Fu组，未用药的对照组。经随访观察发现LAK组出现腹膜种植转移者2年只有7％（2／27），明显少于另外两组。因此文章指出：①LAK细胞／rIL－2腹腔灌注能有效的预防胃癌根治术后的腹腔种植转移，临床推广使用俾有助于生存率的提高；②鉴于LAK细胞的杀伤特性，阐明其真正价值是用于预防癌根治后的转移；③只有LAK细胞数量超过癌细胞数时才能有效的发挥其作用。

Patients with stage Ⅲ gastric cancer were divided into 3 groups.The first group was instilled intraperitoneally with LAK cells and rIL-2 after operation. The second group was instilled with 5-Fu and the third with no instillation as control. After 2 years follow up, only 7 % (2/27 ) of the patients in the first group developed peritoneal metastasis which was significantly lower than those of the other two. Hence it is concluded that: 1 )Instillation of LAK cells and rlL-2 can efficiently prevent peritoneal metastasls after gastrectomy. 2)In light of its action characteristics,the practical role of LAK cells probably is prevention of peritoneal deposit rather than direct effect on the gastric cancer itself. 3)To better the effect,the amount of LAK cells used must exceed that of cancer cells.