nm23-H_1mRNA表达与肾母细胞瘤临床行为的关系

Correlation between nm23-H_1 mRNA and the Clinical Behavior of Nephroblastoma

应用Northernblot分子杂交技术，检测30例肾母细胞瘤及其对应正常肾组织中nm23－H1mRNA表达。通过nm23－H1mRNA水平的比较及其与临床病理的分析，发现肾母细胞瘤nm23－H1mRNA呈低表达，随着病程的演进和转移的出现，肿瘤细胞中nm23－H1mRNA表达水平呈显著性降低，与肿瘤的病理类型无显著相关性（P＞0．05）。提示nm23－H1RNA低表达可能是肾母细胞瘤演进和转移的重要因素。

The mRNA expression of nm23-H1 gene was examined with Northern blot hybridization in resected nephroblastomas and their corresponding normalkidney tissues from 30 patients. Further statistical investigation showed that nm23-H1 gene expression was at low level in nephroblastomas. The average level of nm23-H1 gene expression was significantly decreased with the progression and metastasis of tumors. There was no correlation between reduced expression of nm23-H1 gene and pathologic types of nephroblastoma. The result suggested that reduced expression of nm23-H1 gene might play an important role in the tumor progression and metastasis.