Ⅰ期喉癌放疗失败因素分析

Failure of Radiotherapy in the Treatment of StageⅠCancer of Larynx

1976～1990年收治Ⅰ期喉癌（T1N0M0）88例，采用常规分割放疗，照射剂量为DT70Gy／7周。分析放疗效果及失败因素，总的5年生存率为72．7％；其中声门型为82．1％，声门上型为56．2％；高分化鳞癌为78．3％，低分化鳞癌为96．1％，未分化病为100％，乳头状瘤癌变为33．3％，腺癌为25％，腺鳞癌、腺样囊性疾、喉粘膜白斑癌变均为剧。在选择治疗方案时，对于病理类型属于放射敏感性差、控制率低的癌，或肿瘤为声门上型，可适当考虑首选手术切除，以达到首次治疗最大限度控制肿瘤的目的。

Eighty-eight cases of Stage -Ⅰ cancer of larynx were treated with conventional fractionation irradiation in the period of 1976-1990. The overall 5-year local control rate was 72. 7%. However the same rate varied very much with the site and the pathologic type of the lesion. For less radiosensitive lesions such as supraglottic carcinomas surgical excision seemingly more preferable.