自制支气管封堵器介入性肺叶切除实验研究

Experiment Study of Self-made Bronchial Occlusive Equipment for Interventional Pulmonary Lobectomy in Dogs

目的:探讨运用自制支气管封堵器行介入性肺叶切除的可行性。方法::健康犬12只随机分成3组,每组4只,A、B组行靶肺支气管肺泡灌注平阳霉素-碘化油乳剂,A组用支气管封堵器堵塞靶支气管,B组用骨水泥堵塞靶支气管,C组为空白对照组。分别于术后28d及56d取肺组织,测定肺纤维化的程度。结果:A、B组动物均示肺不张形成,组织病理学显示靶肺呈纤维化改变;A、B组非靶肺与C组双肺均未见明显纤维化。结论:通过支气管肺泡灌注平阳霉素-碘化油乳剂后堵塞靶支气管可达到介入性肺叶切除目的,其中使用国产支气管封堵器比骨水泥行介入性肺叶切除术更方便,是一种安全简便的方法。

Objective：To study the feasibility of interventional pulmonary lobectomy （IPLT） in dogs used self made bronchial-occlusive equipment. Methods： 12 healthy dogs were divided into three groups randomly （n 4 for each）. In group A and B, pingyangmycin and lipoidal emulsion （PLE） was injected into the target lung via bronchial catheter. Bronchial occlusive equipment in Group A and polymethylmethacrylate （PMMA） in Group B was used to obstruct the target bronchus. Group C was the control group. The experimental animals were sacrificed on the 28th and 56th day respectively, the lung tissue was sent for pathological examination. The degree of pulmonary fibrosis were measured under microscope. Results： Atelectasis and pulmonary fibrosis were revealed in the target lung both in Group A and B. Pulmonary fibrosis was not found in non-target lung of Group A and B as well as group C. Conclusion： IPLT could be obtained after injection of PLE into the target lung in combination with occlusion of the target bronchus. Using self-made bronchial occlusive equipment was a safe and efficient approach for IPLT,which was more convenient than using PMMA.