输卵管妊娠患者沙眼衣原体及解脲脲原体检测

Chlamydia Trachomatis and Ureaplasma Urealyticum Infection in Patients with Tubal Pregnancy

目的：探讨生殖道沙眼衣原体（ＣＴ）和解脲脲原体（ＵＵ）感染与输卵管妊娠的关系。方法：采用聚合酶链反应方法，检测３４例输卵管妊娠患者（输卵管妊娠组）的宫颈分泌物、输卵管组织、盆腔液中ＣＴＤＮＡ及ＵＵＤＮＡ，同时选择２８例输卵管结扎妇女（输卵管结扎组）和４０例正常早孕妇女（正常早孕组）作为对照。结果：输卵管妊娠组宫颈分泌物ＣＴＤＮＡ和ＵＵＤＮＡ阳性检出率分别为４７．１％和５５．９％，高于输卵管结扎组和正常早孕组（Ｐ＜０．０５）；输卵管妊娠组患者的输卵管组织ＣＴＤＮＡ阳性检出率为２６．５％，高于输卵管结扎组（Ｐ＜０．０５）；输卵管妊娠组与输卵管结扎组输卵管组织ＵＵＤＮＡ及盆腔液ＣＴＤＮＡ和ＵＵＤＮＡ阳性检出率比较，差异无显著性（Ｐ＞０．０５）。结论：输卵管妊娠与生殖道ＣＴ和ＵＵ感染有关。

Objective: To explore the relationship between genital infections with chlamydia trachomatis (CT) and ureaplasma urealyticum (UU) and tubal pregnancy. Methods: 34 patients with tubal pregnancy (case group), 28 women undergoing tubal ligation (control group A) and 40 women with normal early intrauterine pregnancy (control group B) were investigated as a case control study. The polymerase chain reaction (PCR) technique was used to detect CT DNA and UU DNA in samples from the secretion of cervix, fallopian tube and pelvic fluid. Results: Case group was more likely to have detectable CT DNA (47.1%) and UU DNA (55.9%) from cervical secretion than control group A and B ( P <0.05). CT DNA detective rate from fallopian tube was significantly higher in case group than the control group A (26.5% versus 3.6%, P <0.05). There were no significant differences in the positive rates of UU DNA from fallopian tube, CT DNA and UU DNA from pelvic fluid between case group and control group A. Conclusion: There is a strong association between tubal pregnancy and genital infection with CT and UU.