经肝动脉和门静脉CO_2超声造影在肝癌动物模型中的比较

COMPARATIVE ANALYSES OF CO2 ENHANCED ULTRASONOGRAPHY BETWEEN TRANSHEPATIC ARTERY AND TRANSPORTAL VEIN IN RATS WITH HEPATIC TUMOR

研究肝癌动物模型的ＣＯ２超声造影（ＣＯ２－ＥＵＳ），以探讨经肝动脉和经门脉ＣＯ２－ＥＵＳ在诊断肝癌中的差异及可行性。３６只接种Ｗａｌｋｅｒ－２５６瘤株的肝癌鼠分两组，分别行肝动脉和门脉途径的ＣＯ２－ＥＵＳ。结果：鼠肝癌在经肝动脉ＣＯ２－ＥＵＳ中可表现高回声、低回声、斑块及环状增强４种类型，可根据不同表现提示肿瘤坏死与否等情况。经门脉 ＣＯ２－ＥＵＳ均显示肝癌为低回声型，并不能提示肿瘤内病理改变等情况。结论：两种方法的ＣＯ２－ＥＵＳ均可提高小肝癌的检出（最小为３ｍｍ），而经肝动脉ＣＯ２－ＥＵＳ可反映肿瘤内血供情况。

The difference of CO2 enhanced ultrasonography (CO2-EUS) by transhepatic artery and transportal vein was studied in the diagnosis of liver tumor in rats. METHODS Thirty six Wistar rats with Waker-256 liver tumor were divided into two groups. CO2-EUS via hepatic artery was carried out in one of the groups (A group), and portal vein, in the another (B group). RESULTS The liver tumor of A group displayed hyperechoic, hypoechoic, spotty hyperechoic and ringlike hyperechoic pattes, which represented the pathologic character of liver tumor. The hypoechoic pattern was the only finding shown in the liver tumor of B group.and the pathologic changes were not demonstrated. The detection rates of both methods for rat liver tumlor were 100 % and the minimal diameter of tumor was 3 mm. CONCLUSIONS CO2-EUS via hepatic artery and portal vein can improve the detection rates of small liver tumor. However, CO2-EUS via hepatic artery may better reflect the blood supply of the hepatic tumors.