反复呼吸道感染病儿红细胞免疫和体液免疫功能的变化

THE ALTERATION OF RED CELL IMMUNE AND HUMORAL IMMUNE FUNCTIONS IN CHILDREN WITH REPEATED INFECTION OF RESPIRATORY TRACT

①目的探讨反复呼吸道感染（ＲＩＲ）病儿红细胞免疫和体液免疫功能的变化。②方法检测了３０例ＲＩＲ病儿红细胞免疫和体液免疫功能（ＩｇＧ，ＩｇＭ，ＩｇＡ，补体Ｃ３）的变化，并与５２例健康儿童进行了对照。③结果ＲＩＲ病儿红细胞Ｃ３ｂ受体花环率（ＲＣＲ）明显降低，循环免疫复合物（ＣＩＣ）阳性率明显增高，与对照组相比差异有显著性（ｔ＝１１．４２３，χ２＝６５．９９，Ｐ＜０．０１），而红细胞免疫复合物花环率（ＲＩＣＲ）与对照组相比差异无显著意义（ｔ＝０．７２０，Ｐ＞０．０５）。病儿红细胞促中性细胞吞噬补体调理的酵母菌作用减弱（ｔ＝８．１６６，１３．７００，Ｐ＜０．００１）。同时，病儿血清ＩｇＡ，ＩｇＧ，补体Ｃ３含量较对照组明显降低（ｔ＝６．７５６～８．２７６，Ｐ＜０．０１）。ＲＣＲ与ＩｇＡ，ＩｇＧ和补体Ｃ３含量呈正相关（ｒ＝０．４１２～０．４９７，Ｐ＜０．００１）。④结论红细胞免疫和体液免疫参与了ＲＩＲ发病，且其变化与病情严重程度有关。

Objective To study the effect of red cell immune and humoral immune functions in sick children with repeated infection of respiratory tract(RIR). Methods Thirty cases of RIR were studied by measuring red cell immune and humoral immune functions(IgG, IgM, IgA, C 3), and 52 health children were as controls. Results Red cell C 3b receptor rosette rate(RCR) was significantly lower and positive rate of circulating immune complex(CIC) was higher in sick children than in the control( t=11.423,χ 2=812.38,P <0 01). There was no difference of red cell immune complex rosette rate(RICR) between the two groups( t=0.720,P >0 05). The ability of red cell in sick children to enhance the phagocytosis of micro organisms by neutrophils was markedly reduced( t=9.166,13.700,P <0 001). The content of serum IgA, IgG and C 3 were lower in sick children than that in the control( t=8.167,6.276,P <0 01), and RCR in sick children was positively correlated with the content of serum IgA, IgG and C 3( r=0.412￣0.497,P <0 001). Conclusions Red cell immune and humoral immune functions are involued in the pathogenesis of RIR, and their changes have some relation to the degree of disease.