摘要
①目的探讨国产磺甲唑对鼠伤寒沙门氏菌的致突变作用。②方法用鼠伤寒沙门氏菌的组氨酸缺陷性突变菌种ＴＡ９７，ＴＡ９８，ＴＡ１００和ＴＡ１０２，在加或不加肝微粒体酶系的情况下测试国产磺甲唑的致突变作用。③结果国产磺甲唑对４种突变菌株的回变菌落数不超过自发回变数的２倍。④结论在本试验条件下，国产磺甲唑无致突变作用。
Objective To study the mutagenicity of sulmazole in salmonella typhimurium Methods The mutagenicity effect of sulmazole was studied in 4 histidine requiring strains of salmonella typhimurium in the presence or absence of liver microsomal metabolic activation Results The number of reversion colony caused by sulmazole of the 4 mutants did not exceed the double number of the spotaneous reversion of the 4 mutants. Conclusion Sulmazole does not have the mutagenic effect on TA97, TA98, TA100 and TA102 at the dose used.
出处
《青岛医学院学报》
1997年第1期67-68,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
磺甲唑
致突变作用
鼠伤寒
沙门氏菌
毒理学
sulmazole
mutagenicity test
microsomes, liver
toxicology
salmonella typhimurium
