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国产磺甲唑对鼠伤寒沙门氏菌的致突变作用 被引量:1

MUTAGENICITY OF SULMAZOLE IN SALMONELIA TYPHIMURIUM
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摘要 ①目的探讨国产磺甲唑对鼠伤寒沙门氏菌的致突变作用。②方法用鼠伤寒沙门氏菌的组氨酸缺陷性突变菌种TA97,TA98,TA100和TA102,在加或不加肝微粒体酶系的情况下测试国产磺甲唑的致突变作用。③结果国产磺甲唑对4种突变菌株的回变菌落数不超过自发回变数的2倍。④结论在本试验条件下,国产磺甲唑无致突变作用。 Objective To study the mutagenicity of sulmazole in salmonella typhimurium Methods The mutagenicity effect of sulmazole was studied in 4 histidine requiring strains of salmonella typhimurium in the presence or absence of liver microsomal metabolic activation Results The number of reversion colony caused by sulmazole of the 4 mutants did not exceed the double number of the spotaneous reversion of the 4 mutants. Conclusion Sulmazole does not have the mutagenic effect on TA97, TA98, TA100 and TA102 at the dose used.
出处 《青岛医学院学报》 1997年第1期67-68,共2页 Acta Academiae Medicinae Qingdao Universitatis
关键词 磺甲唑 致突变作用 鼠伤寒 沙门氏菌 毒理学 sulmazole mutagenicity test microsomes, liver toxicology salmonella typhimurium
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