897例泌尿系感染主要病原菌耐药性分析

Analysis of the Primary Bacterial Resistance in the Diagnosis of 897 Sample with Urinary Tract Infection

目的：通过对引起泌尿系感染的主要病原菌进行耐药性分析，了解本院泌尿系感染病原菌的分布及对抗菌药物的耐药情况，从而更好地配合临床医生合理用药。方法：收集897例患者尿液行中段尿培养，按《全国临床检验操作规程》进行检测分析。结果：检出尿中细菌数高于10^4～10^5CFU／ml有424例，阳性率47．3％。其中革兰氏阴性菌308株（72．6％），以大肠埃希菌为主（232株）。阳性菌116株（27．4％），以表皮葡萄球菌为主（68株）。232株大肠埃希菌对8种抗生素的耐药性分别为：环丙沙星52．2％，阿米卡星4．3％，头孢曲松26．3％，左氧氟沙星27．6％，氨苄西林89．2％，头孢唑啉48．7％，头孢哌酮-舒巴坦3．0％，头孢他啶18．5％。68株表皮葡萄球菌对8种抗生素的耐药性分别为：头孢哌酮-舒巴坦2．9％，阿米卡星5．9％，复方新诺明38．2％，左氧氟沙星17．6％，青霉素75．0％，苯唑西林42．6％，克林霉素61．8％，红霉素44．1％。结论：长时间和较频使用的抗生素会导致耐药性的产生，提示在选择使用抗生素时必须慎重，防止滥用。

Ojective To analyse the primary bacterial resistance for the diagnosis of urinary tract infection, research the distributing and the bacterial resistance, which could help the doctors to prescribe properly. Methods Collect and cultivate urine sample were obtained from 897 patients. The instruction process determing by 《China clinical inspect procedure》.Results 424 results were higher than 10^4-10^5CFU/ml, positive tate： 47.3%.And 308 sample were G- bacterium, lots of them were E. coliform 116 positive sample （27.4%）,some were S. epidermidis （68 sample）.The resistance about 8 kinds antibiotics of 232 E. coliform were： ciprofloxacin 52.2%,amikacin4.3%,ceftriaxone26.3%,fleroxacin27.6%,ampicillin89.2%,cefazolin48.7%,cefoperazone-sulbactam 3.0%, ceftazidime18.5%. The resistance about 8 kinds antibiotics of 68 S. epidermidis were： cefoperazone-sulbactam 2.9%,amikacin 5.9%,SMZ-TMP 38.2%,fleroxacin 17.6%,penicillin75. 0%,oxacillinsodium42.6%,clindamycin61.8%,erythromycin44.1%.Conclusions The bacterial resistance would come along with abuse the antibiotics, so we must use the antibiotics rational.