全身炎症反应综合征患儿血清TNF-α与IL-6及IL-10的动态观察及意义

Dynamic Changes and the Significance of Serum TNF-α,IL-6 and IL-10 in Children with the Systemic Inflammatory Response Syndrome

目的：探讨全身炎症犀应综合征（SIRS）患儿血清TNF-α、IL-6、IL-10的动态变化及意义。方法：采用酶联免疫吸附法（ELISA）检测52例SIRS患儿入院后第1天、第3天、第5天血清TNF-α、IL-6、IL-10的含量。结果：血清TNF-α、IL-6、IL-10的含量，SIRS组均比对照组明显增高（P〈0．05），且上述各项指标在MODS组和死亡组均维持在较高水平。结论：TNF-α、IL-6、IL-10的含量可反映SIRS患儿病情严重程度，为临床早期诊断、判断病情轻重、估计预后提供依据。

Objective To study the dynamic changes and the significance of serum TNF-α, IL-6, IL-10 in children with the systemic inflammatory response syndrome （SIRS）. Methods Fifty-tow cases with SIRS were selected. The level of TNF-α, IL- 6 ,IL-10 were determined using ELISA on first day, Third day and fifth day. Results The levels of TNF-α ,IL-6 and IL-10 in the SIRS group were remarkably higher than those in the control groups（ P 〈 0.05 ）. Moreover, these indexes of the MODS ca- ses and the death cases remained high continuously. Conclusion TNF-α, IL-6 and IL-10 may be valuable in assessing the degree of severity and the prognosis of the children with SIRS. They are heipful in making effective treatments and preventive measures for SIRS.